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Following the finding that the cancer cell lines did not elevate telomerase enzyme activity upon epitalon treatment but did elongate telomeres, we investigated the other commonly used mechanism to extend telomeres in mammals, ALT (Alternative Lengthening of Telomeres)
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The clinical presentation can be insidious, with symptoms developing so gradually that patients may not recognise the changes until deficiency becomes severe
doi: 10.1186/s13046-018-1017-7
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